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Lomotil ?
  1. #1
    abey042000 is offline Member
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    Default Lomotil ?

    I everyone, and thanks to all who replies. I have heard or read somewhere where the RX-Lomotil can be used during CT-WD off opiates. I'm thinking i heard that it's an opiate? I have some here, so just curious to see if this would help me. Any sugg.,info, or comments welcome.

  2. #2
    zippysgoddess is offline Platinum Member
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    Lomotil is Diphenoxylate Hydrochloride and Atropine Sulfate, it is related to the narcotic Meperidine, but not an opiate in itself, but alot of them that act on the same receptors like that do help with withdrawal symptoms.



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  3. #3
    abey042000 is offline Member
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    How is Lomitol related to demeral. when i did a search on it, it didnt state anything about that connection. I was just curious if anyone else had anymore info. Thanks so much, also, Zippy

  4. #4
    zippysgoddess is offline Platinum Member
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    Well, the Meperidine that I mentioned above is what is the active ingredient in Demerol. So they are related, and act in similar ways, but the Lomitol is not a narcotic, so while it can act similarly and help alleviate withdrawals, it does not do all of the same things, this is similar to the way Suboxone acts for recovering addicts that use it, it acts on those same receptors, to help with withdrawal symptoms so they aren't so severe, but it doesn't cause the high feeling or euphoria that is what most addicts are looking for, so they don't enjoy it like they would the other drugs, so it gets them out of that habit. And since it can help stop the withdrawals, this can be used to slowly taper off of narcotics.



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  5. #5
    abey042000 is offline Member
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    Once again Zippy, thanks so much! I found the info for the ingred. or same as demerol, but hadn't been able to find info on the Lomotil. Lord, Bless ya!

  6. #6
    nenene is offline New Member
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    Actually, Lomotil is considered to be a narcotic and is a controlled substance. It is only a controlled IV or V (I dont remember which), it can become very addictive. People ingest six or eight at a time and unfortunately, get high from them, and get addicted. I have seen it happen. Also, people who used them a lot had severe problems with diarrhea and dehydration. I dont want to give any advice regarding using it to help with withdrawal though. I am not a physician.

    I am a licensed pharmacist who has not practiced for more than a year now, so my identification skills may be rusty. Also, I make mistakes too!

  7. #7
    abey042000 is offline Member
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    Thanks Nenene~

    What about the atrophine in it? Do u know anything about it? I read somewhere that their is a negative side to ingesting alot of the atrophine. Any info would be great about this.

  8. #8
    zippysgoddess is offline Platinum Member
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    When I said non-narcotic, I was basing it on the monographs that I read online. The ones I saw all say it isn't, but it is related to narcotics, they list it as an antidiarrheal med, with some other uses.

    Ah well. Such is life. One again, nenene, you and I must agree to disagree! LOL!

    Anyway for more information, side effects, dangers etc. here are some links:

    http://www.drugs.com/mtm/l/lomotil.html

    http://www.drugs.com/cons/lomotil_systemic.html

    "Diphenoxylate and atropine (dye-fen-OX-i-late and A-troe-peen) is a combination medicine used along with other measures to treat severe diarrhea in adults. Diphenoxylate helps stop diarrhea by slowing down the movements of the intestines.

    Since diphenoxylate is chemically related to some narcotics, it may be habit-forming if taken in doses that are larger than prescribed. To help prevent possible abuse, atropine (an anticholinergic) has been added. If higher than normal doses of the combination are taken, the atropine will cause unpleasant effects, making it unlikely that such doses will be taken again."

    http://www.rxlist.com/cgi/generic3/diphenoxylate.htm

    http://www.pfizer.com/pfizer/download/uspi_lomotil.pdf (Must have adobe for this one!)

    http://www.gicare.com/pated/diphenoxylate_atropine.htm

    "This drug is a mixture of two medications, each of which can slow the bowel action. It has been around a long time and has a good safety record. However, diphenoxylate is derived from narcotics and, while it does not have any pain relieving or addiction problems, it is not recommended for chronic use."


    http://ibscrohns.about.com/od/prescr...lomotilfaq.htm

    http://en.wikipedia.org/wiki/Lomotil








    My information is not guaranteed correct. I do not get them right all the time, but I do enjoy the hunt~

  9. #9
    abey042000 is offline Member
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    Zippy~
    Thanks for taking the extra time to send me those sites. I appreciate hon! Have a good night and may the Lord Bless You!

  10. #10
    zippysgoddess is offline Platinum Member
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    Very welcome, I hope you can find some info that will help!



    My information is not guaranteed correct. I do not get them right all the time, but I do enjoy the hunt~

  11. #11
    pharmd06 is offline Member
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    Lomotil Is a scheduled V substance.

    Diphenoxylate alone is a Scheduled II narcotic.

    Diphenoxxylate is an opiate agonist (works just like all other opiates).

    Atropine is added to make lomotil bc you cannot take high doses of atropine without terrible side effects. if diphenoxylate was used alone it could be abused like any other narcotic by taking high doses. the addition of atropine makes it less addictive bc of the potenial side effects.

    lomotil can be used in withdrawal bc the opiate actions of diphenoxylate.

    m

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