Peoples bodies react differently to transdermal patches. Fent is fat soluble so the medication is absorbed through the skin and into the blood stream. The rubbing directlyon the skin is not a good idea, but is better than IV like a lot of dumb people do. The medications time release is in the patch not in the medication like a pills extended release. I knew more than one person who passed away eating and shooting fent. It is not smart, and absorbtion through the skin can vary due to things like temperature and placement of the analgesic. The skin is very good at protecting so some people just do not absorb like others. You can try applying pressure using some type of waterproof tape or asking the doctor to prescribe something a little more orthodox such as
oxycodone or
morphine. You should also note that the amount of fat has nothing to do with how much it is absorbed. The site/ placement of the patch should be rotated 2-4 days mind you, so that could be why it is not working to the height of it's ability. Body hair should be trimmed if heavy near the patch site. Most people just slap it on their arm and call it 72hrs even though it feels more like 60hrs give or take. I would rotate/shave/clean/moisturize the area and then secure the patch with some tegaderm. - Dan Source: I know my opiates and had my experiences with them. I only educate now.