Have you seen the info in the PDR at drugs.com?
Maximum Recommended Dose: The dose of AVANDIA should not exceed 8 mg daily, as a single dose or divided twice daily. The 8 mg daily dose has been shown to be safe and effective in clinical studies as monotherapy and in combination with metformin. Doses of AVANDIA greater than 4 mg daily in combination with a sulfonylurea have not been studied in adequate and well-controlled clinical trials. Doses of AVANDIA greater than 4 mg daily in combination with insulin are not currently indicated.
JJ