most sources say 10-15 grams of apap can produce liver failure and dosages exceeding 25 grams can be fatal. However, the greater danger is chronic daily use of high doses esp coupled with other drugs with a high liver load (like alcohol). If you are taking apap every day, you should not exceed the reccomended dose of your dr or the directions on any bottle of
tylenol ES (mine says no more than 8 a day (or 4000mg a day), but this is with no alcohol or other drugs.
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