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Originally Posted by Dimplez626  I really need your help. I am 32 years old and I also have Bi-Polar as well as ADHD. I was just recently put on Adderall 20mg for about 2 weeks. It did nothing for me. So my doctor increased it to Adderall 30mg. I have been on this dose for about 2 weeks now and still nothing. No side effects or anything. I also take Depakote as well as Neurontin, Seroquel, Zyprexa & Trazadone. My Bi-Polar is pretty much under control. Now I need to figure out when the Adderall is going to start working. I have read quite a bit of stories here and it seems like Adderall really works. I really hope it starts working soon.
I was wondering what dosage worked for you? Are you taking Adderall or Adderall XR?
Any information and/or advise would be greatly appreciated.
Thank you. |
I believe your problem is not a result of the Adderall dose, but the other medications you are taking with Adderall.
First of all, Adderall is a
Norepinephrine & Dopamine Reuptake Inhibitor (NDRI). NDRIs
increase the levels of the neurotransmitters norepinephrine & dopamine stimulating the nerve cells and the frequency at which do so. Neuron stimulation occurs when a chemical binds to neuron receptors and stimulation of the nerve cells by dopamine and norepinephrine results in Adderall's CNS stimulant effect.
Zyprexa & Seroquel are dopamine antagonists (as well as an antagonist of other chemicals but dopamine is the one interacting the most with Adderall). A
dopamine antagonist blocks dopamine from binding to receptors and stimulating the brain's nerve cells, blocking the CNS stimulant effect that dopamine stimulation causes.
It is thought that Adderall is an effective treatment for ADHD as a result of the increase in dopamine binding and stimulation of the neurons that causes the CNS stimulant effect. Seroquel & Zyprexa blocks dopamine receptors and if dopamine can not bind to neuron receptors, dopamine can not stimulate the CNS and produce the effects of Adderall that make it useful in the treatment of ADHD.
Therefore an interaction may be occuring between Adderall, Zyprexa, & Seroquel that is blocking Adderall's effects.