Avandia (rosiglitazone) and Alcohol / Food Interactions
There are 3 alcohol/food/lifestyle interactions with Avandia (rosiglitazone) which include:
Alcohol (Ethanol) ↔ rosiglitazone
Moderate Drug Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Alcohol may cause hypoglycemia or hyperglycemia in patients with diabetes. Hypoglycemia most frequently occurs with chronic drinking of large amounts of alcohol. However, it may also occur after binge drinking or moderate drinking, especially when the alcohol is ingested on an empty stomach. The mechanism involves inhibition of gluconeogenesis as well as the counter-regulatory response to hypoglycemia. Episodes of hypoglycemia may last for 8 to 12 hours after ethanol ingestion. By contrast, chronic alcohol abuse may cause impaired glucose tolerance and hyperglycemia. Moderate alcohol consumption generally does not affect blood glucose levels in patients with well controlled diabetes. A disulfiram-like reaction (e.g., flushing, headache, and nausea) has been reported frequently with chlorpropamide and very rarely with other sulfonylureas.
MANAGEMENT: Patients with diabetes should avoid consuming alcohol if their blood glucose is not well controlled, or if they have hypertriglyceridemia, neuropathy, or pancreatitis. Patients with well controlled diabetes should limit their alcohol intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz wine, 12 oz beer, or 1.5 oz distilled spirits) in conjunction with their normal meal plan. The alcohol should be consumed with a meal.
High Blood Pressure (Hypertension)
Moderate Potential Hazard, High plausibility
thiazolidinediones - edema
Thiazolidinediones can cause dose-related edema. Therapy with thiazolidinediones should be administered cautiously in patients at risk for congestive heart failure as well as those with fluid overload or other conditions that may be adversely affected by excess fluid such as hypertension. Patients should be monitored for signs and symptoms of heart failure such as dyspnea, swelling of legs or ankles, and weight gain. Obesity
Moderate Potential Hazard, High plausibility
thiazolidinediones - weight gain
Thiazolidinediones can cause dose-related weight gain, which may be undesirable in obese patients attempting to lose weight. The mechanism of weight gain is unclear but probably involves a combination of fluid retention and fat accumulation. In postmarketing experience with rosiglitazone, there have been reports of unusually rapid increases in weight and increases in excess of that generally observed in clinical trials. Patients who experience such increases should be assessed for fluid retention and volume-related events such as excessive edema and congestive heart failure.You should also know about...
Avandia (rosiglitazone) drug Interactions
There are 609 drug interactions with Avandia (rosiglitazone)
Avandia (rosiglitazone) disease Interactions
There are 8 disease interactions with Avandia (rosiglitazone) which include:
Myocardial Infarction- Chf
Edema- Liver Disease
- Premenopausal Anovulation
- Type I Diabetes
- Weight Gain
- Anemia
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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