Repaglinide Alcohol, Food & Lifestyle Interactions

There are 2 food and lifestyle interactions with repaglinide which include:

GENERALLY AVOID: Alcohol may cause hypoglycemia or hyperglycemia in patients with diabetes. Hypoglycemia most frequently occurs with chronic drinking of large amounts of alcohol; however, it may also occur after binge drinking or moderate drinking, especially when the alcohol is ingested on an empty stomach. The mechanism is inhibition of gluconeogenesis and inhibition of the counterregulatory response to hypoglycemia. Hypoglycemia may last for 8 to 12 hours after ethanol ingestion. Chronic alcohol abuse may cause impaired glucose tolerance and hyperglycemia. Moderate alcohol consumption generally does not affect blood glucose levels in patients with well-controlled diabetes. In addition, a disulfiram-like reaction (flushing, headache, and nausea) has been reported frequently with chlorpropamide and very rarely with other sulfonylureas.

MANAGEMENT: Patients with diabetes should avoid alcohol if they experience flushing, headache, or nausea after alcohol ingestion, if their blood glucose is not well controlled, or if they have hypertriglyceridemia, neuropathy, or pancreatitis. Patients with well-controlled diabetes should limit their intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz. wine, 12 oz. beer, or 1.5 oz. distilled spirits) in addition to their meal plan. The alcohol should be consumed with a meal.

MONITOR: Grapefruit juice may increase the plasma concentrations of some orally administered drugs that are primarily metabolized by the CYP450 3A4 isoenzyme. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The extent and clinical significance of many of these interactions are unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.

MANAGEMENT: Patients who regularly consume grapefruits and grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that are metabolized by CYP450 3A4. Grapefruits and grapefruit juice should be avoided if an interaction is suspected. Orange juice is not expected to interact with these drugs.

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repaglinide drug Interactions

There are 759 drug interactions with repaglinide

repaglinide disease Interactions

There are 3 disease interactions with repaglinide which include:

Cardiovascular Risk Liver Disease

Hypoglycemia

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