Methylprednisolone and Alcohol / Food Interactions

There are 3 alcohol/food/lifestyle interactions with methylprednisolone which include:

MONITOR: Grapefruit juice may increase the plasma concentrations of orally administered drugs that are substrates of the CYP450 3A4 isoenzyme. However, the interaction seems to affect primarily those drugs that undergo significant presystemic metabolism by CYP450 3A4 (i.e., drugs with low oral bioavailability), presumably due to the fact that grapefruit juice inhibits intestinal rather than hepatic CYP450 3A4. Because pharmacokinetic interactions involving grapefruit juice are often subject to a high degree of interpatient variability, the extent to which a given patient may be affected is difficult to predict.

MANAGEMENT: Patients who regularly consume grapefruit or grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that undergo significant presystemic metabolism by CYP450 3A4. Grapefruit and grapefruit juice should be avoided if an interaction is suspected. Orange juice is not expected to interact with these drugs.

corticosteroids - fluid retention

Corticosteroids may cause hypernatremia, hypokalemia, fluid retention, and elevation in blood pressure. These mineralocorticoid effects are most significant with fludrocortisone, followed by hydrocortisone and cortisone, then by prednisone and prednisolone. The remaining corticosteroids, betamethasone, dexamethasone, methylprednisolone, and triamcinolone, have little mineralocorticoid activities. However, large doses of any corticosteroid can demonstrate these effects, particularly if given for longer than brief periods. Therapy with corticosteroids should be administered cautiously in patients with preexisting fluid retention, hypertension, congestive heart failure, and/or renal dysfunction. Dietary sodium restriction and potassium supplementation may be advisable.

corticosteroids - hyperlipidemia

Corticosteroids may elevate serum triglyceride and LDL cholesterol levels if used for longer than brief periods. Patients with preexisting hyperlipidemia may require closer monitoring during prolonged corticosteroid therapy, and adjustments made accordingly in their lipid-lowering regimen.

You should also know about...

methylprednisolone drug Interactions

There are 659 drug interactions with methylprednisolone

methylprednisolone disease Interactions

There are 23 disease interactions with methylprednisolone which include:

(+) Tuberculin Test Electrolyte Imbalance Gi Perforation Infections Mi Ocular Herpes Simplex Pud Scleroderma Strongyloidiasis Depression/Psychoses Diabetes Fluid Retention

Hyperadrenocorticalism Hyperlipidemia Hypothyroidism Liver Disease Myasthenia Gravis Myopathy Ocular Toxicities Osteoporosis Prematurity Thromboembolism Vaccination

See also...

• Methylprednisolone Consumer Information

• Drug Interactions Checker

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