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Medrol and Alcohol/Food Interactions

There are 3 alcohol/food/lifestyle interactions with Medrol (methylprednisolone).

Moderate

methylPREDNISolone food

Moderate Food Interaction

Grapefruit juice may increase the blood levels of certain medications such as methylPREDNISolone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with methylPREDNISolone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Moderate

High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

corticosteroids - fluid retention

Corticosteroids may cause hypernatremia, hypokalemia, fluid retention, and elevation in blood pressure. Large doses of any corticosteroid can demonstrate these effects, particularly if given for longer periods. Therapy with corticosteroids should be administered cautiously in patients with preexisting fluid retention, hypertension, congestive heart failure, and/or renal dysfunction. Dietary sodium restriction and potassium supplementation may be advisable.

References

  1. "Product Information. Hydeltrasol (prednisolone)." Merck & Co., Inc PROD (2001):
  2. "Product Information. Deltasone (prednisone)." Pharmacia and Upjohn PROD (2001):
  3. "Product Information. Decadron (dexamethasone)." Merck & Co., Inc PROD (2001):
  4. "Product Information. Hydrocortone (hydrocortisone)." Merck & Co., Inc PROD (2001):
  5. "Product Information. Medrol (methylprednisolone)." Pharmacia and Upjohn PROD (2001):
  6. "Product Information. Florinef Acetate (fludrocortisone)." Bristol-Myers Squibb PROD (2001):
  7. "Product Information. Cortone Acetate (cortisone)." Merck & Co., Inc PROD (2001):
  8. "Product Information. Kenalog (triamcinolone)." Bristol-Myers Squibb PROD (2001):
  9. "Product Information. Celestone (betamethasone)." Schering Corporation PROD (2001):
  10. "Product Information. Emflaza (deflazacort)." PTC Therapeutics, Inc. SUPPL-5 (2021):
  11. "Product Information. Agamree (vamorolone)." Santhera Pharmaceuticals (US) (2023):
View all 11 references
Moderate

High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Moderate Potential Hazard, Moderate plausibility

corticosteroids - hyperlipidemia

Corticosteroids may elevate serum triglyceride and LDL cholesterol levels if used for longer than brief periods. Patients with preexisting hyperlipidemia may require closer monitoring during prolonged corticosteroid therapy, and adjustments made accordingly in their lipid-lowering regimen.

References

  1. Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42
  2. "Product Information. Hydeltrasol (prednisolone)." Merck & Co., Inc PROD (2001):
  3. "Product Information. Deltasone (prednisone)." Pharmacia and Upjohn PROD (2001):
  4. "Product Information. Decadron (dexamethasone)." Merck & Co., Inc PROD (2001):
  5. "Product Information. Hydrocortone (hydrocortisone)." Merck & Co., Inc PROD (2001):
  6. "Product Information. Medrol (methylprednisolone)." Pharmacia and Upjohn PROD (2001):
  7. "Product Information. Florinef Acetate (fludrocortisone)." Bristol-Myers Squibb PROD (2001):
  8. "Product Information. Cortone Acetate (cortisone)." Merck & Co., Inc PROD (2001):
  9. "Product Information. Kenalog (triamcinolone)." Bristol-Myers Squibb PROD (2001):
  10. "Product Information. Celestone (betamethasone)." Schering Corporation PROD (2001):
View all 10 references

Medrol drug interactions

There are 586 drug interactions with Medrol (methylprednisolone).

Medrol disease interactions

There are 23 disease interactions with Medrol (methylprednisolone) which include:


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.