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Megestrol and Alcohol/Food Interactions

There is 1 alcohol/food/lifestyle interaction with megestrol.

Moderate

High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

estrogens/progestogens - fluid retention

Estrogens and progestogens may cause fluid retention, particularly when given in high dosages or for prolonged periods. Therapy with these agents should be administered cautiously in patients who have preexisting problems with excess fluid. In addition, patients with conditions that may be adversely affected by fluid accumulation, such as asthma, epilepsy, migraine, and cardiovascular or renal dysfunction, should be observed for exacerbation of their condition during estrogen and/or progestogen therapy.

References

  1. Leiman G "Depo-medroxyprogesterone acetate as a contraceptive agent: its effect on weight and blood pressure." Am J Obstet Gynecol 114 (1972): 97-102
  2. "Product Information. Depo-Provera (medroxyprogesterone)." Pharmacia and Upjohn PROD (2001):
  3. "Product Information. Provera (medroxyprogesterone)." Pharmacia and Upjohn PROD (2001):
  4. "Product Information. Premarin (conjugated estrogens)." Wyeth-Ayerst Laboratories PROD (2001):
  5. "Product Information. Climara (estradiol)." Berlex Laboratories PROD (2001):
  6. "Product Information. Estrace (estradiol)." Warner Chilcott Laboratories PROD (2001):
  7. "Product Information. Estraderm (estradiol)." Ciba-Geigy Pharmaceuticals PROD (2001):
  8. "Product Information. Vivelle (estradiol)." Ciba-Geigy Pharmaceuticals PROD (2001):
  9. "Product Information. Ortho-Novum 10/11 (ethinyl estradiol-norethindrone)." Ortho McNeil Pharmaceutical
  10. "Product Information. Ortho-Cept (desogestrel-ethinyl estradiol)." Ortho McNeil Pharmaceutical PROD (2001):
  11. "Product Information. Demulen 1/50 (ethinyl estradiol-ethynodiol)." Searle PROD
  12. "Product Information. Triphasil (ethinyl estradiol-levonorgestrel)." Wyeth-Ayerst Laboratories PROD (2001):
  13. "Product Information. Ortho-Cyclen (ethinyl estradiol-norgestimate)." Ortho McNeil Pharmaceutical PROD (2001):
  14. "Product Information. Lo/Ovral (ethinyl estradiol-norgestrel)." Wyeth-Ayerst Laboratories PROD (2001):
  15. "Product Information. Ortho-Novum 1/50 (mestranol-norethindrone)." Ortho McNeil Pharmaceutical
  16. "Product Information. Emcyt (estramustine)." Pharmacia and Upjohn PROD (2001):
  17. "Product Information. Megace (megestrol)." Bristol-Myers Squibb PROD (2001):
  18. "Product Information. Ortho-Est (estropipate)." Ortho McNeil Pharmaceutical PROD (2001):
  19. "Product Information. Ortho Dienestrol (dienestrol topical)." Ortho McNeil Pharmaceutical PROD
  20. "Product Information. Ogen (estropipate topical)." Pharmacia and Upjohn PROD (2001):
  21. "Product Information. Estinyl (ethinyl estradiol)." Schering Corporation PROD
  22. "Product Information. Estratab (esterified estrogens)." Solvay Pharmaceuticals Inc PROD (2001):
  23. "Product Information. Norplant System (levonorgestrel)." Wyeth-Ayerst Laboratories PROD (2001):
  24. "Product Information. Micronor (norethindrone)." Ortho McNeil Pharmaceutical PROD (2001):
  25. "Product Information. Ovrette (norgestrel)." Wyeth-Ayerst Laboratories PROD (2001):
  26. "Product Information. Prometrium (progesterone)." Virtus Pharmaceuticals LLC PROD (2001):
  27. "Product Information. Implanon (etonogestrel)." Organon Pharmaceuticals (2006):
View all 27 references

Megestrol drug interactions

There are 151 drug interactions with megestrol.

Megestrol disease interactions

There are 5 disease interactions with megestrol which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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