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Lorazepam and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with lorazepam.

Moderate

LORazepam food

Moderate Food Interaction

Alcohol can increase the nervous system side effects of LORazepam such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with LORazepam. Do not use more than the recommended dose of LORazepam, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

Obesity

Moderate Potential Hazard, Moderate plausibility

benzodiazepines - obesity

The plasma half-lives of benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat. Marked increases in distribution (> 100%) have been reported for diazepam and midazolam, and moderate increases (25% to 100%) for alprazolam, lorazepam, and oxazepam. Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid toxicity.

References

  1. "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn PROD (2002):
  2. "Product Information. Valium (diazepam)." Roche Laboratories PROD (2002):
  3. "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories PROD (2002):
  4. "Product Information. Serax (oxazepam)." Wyeth-Ayerst Laboratories PROD (2001):
  5. "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation PROD (2001):
  6. "Product Information. Halcion (triazolam)." Pharmacia and Upjohn PROD (2001):
  7. "Product Information. Dalmane (flurazepam)." Roche Laboratories PROD (2001):
  8. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical PROD (2001):
  9. "Product Information. Klonopin (clonazepam)." Roche Laboratories PROD (2001):
  10. "Product Information. Prosom (estazolam)." Abbott Pharmaceutical (2022):
  11. "Product Information. Librium (chlordiazepoxide)." Roche Laboratories PROD (2001):
  12. "Product Information. Doral (quazepam)." Wallace Laboratories PROD (2001):
  13. "Product Information. Versed (midazolam)." Roche Laboratories PROD (2001):
  14. American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
View all 14 references

Lorazepam drug interactions

There are 402 drug interactions with lorazepam.

Lorazepam disease interactions

There are 12 disease interactions with lorazepam which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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