Isoniazid Alcohol, Food & Lifestyle Interactions

There are 2 food and lifestyle interactions with isoniazid which include:

GENERALLY AVOID: Alcoholic patients have been shown to have a higher incidence of INH-induced hepatotoxicity. The mechanism has not been established.

MANAGEMENT: Patients should be counseled to avoid the combination of alcohol and INH and clinicians should be aware of the risk for increased hepatotoxicity in these patients.

ADJUST DOSING INTERVAL: Administration with food significantly reduces isoniazid absorption, increasing the risk of therapeutic failure or resistance. The mechanism is unknown. In addition, the ingestion of certain histamine-rich fish (e.g., tuna) and cheeses during isoniazid therapy may cause a flushing reaction in some patients. The proposed mechanism is inhibition of monoamine oxidase and histaminase by isoniazid, resulting in histamine intoxication.

MANAGEMENT: Isoniazid should be administered on an empty stomach, one hour before or two hours after meals. Patients who experience symptoms such as flushing, tachycardia, chills, headache, nausea, vomiting, diarrhea, burning sensations, sweating, or shortness of breath after eating certain foods should be advised to avoid them.

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isoniazid drug Interactions

There are 355 drug interactions with isoniazid

isoniazid disease Interactions

There are 5 disease interactions with isoniazid which include:

Hepatotoxicity Liver Disease Peripheral Neuropathy

Hemodialysis Renal Dysfunction

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