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Isoniazid and Alcohol / Food Interactions

Drug Interactions (400) Alcohol/Food Interactions (2) Disease Interactions (5)

There are 2 alcohol/food/lifestyle interactions with isoniazid which include:

Isoniazid and Alcohol (Ethanol)

Moderate Drug Interaction

GENERALLY AVOID: Alcoholic patients have been shown to have a higher incidence of INH-induced hepatotoxicity. The mechanism has not been established.

MANAGEMENT: Patients should be counseled to avoid the combination of alcohol and INH and clinicians should be aware of the risk for increased hepatotoxicity in these patients.

Moderate Food Interaction

 

ADJUST DOSING INTERVAL: Administration with food significantly reduces isoniazid absorption, increasing the risk of therapeutic failure or resistance. The mechanism is unknown. In addition, the ingestion of certain histamine-rich fish (e.g., tuna) and cheeses during isoniazid therapy may cause a flushing reaction in some patients. The proposed mechanism is inhibition of monoamine oxidase and histaminase by isoniazid, resulting in histamine intoxication.

MANAGEMENT: Isoniazid should be administered on an empty stomach, one hour before or two hours after meals. Patients who experience symptoms such as flushing, tachycardia, chills, headache, nausea, vomiting, diarrhea, burning sensations, sweating, or shortness of breath after eating certain foods should be advised to avoid them.

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isoniazid drug Interactions

There are 400 drug interactions with isoniazid

isoniazid disease Interactions

There are 5 disease interactions with isoniazid which include:

See also...

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.


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