Clozapine Alcohol, Food & Lifestyle Interactions

There are 2 food and lifestyle interactions with clozapine which include:

Caffeine may increase clozapine serum concentrations and exacerbate psychotic symptoms. The mechanism is unknown but may be related to competition for the same metabolic pathway. No specific intervention is necessary; however, if an interaction is suspected it is recommended that caffeine intake be avoided.

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

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clozapine drug Interactions

There are 935 drug interactions with clozapine

clozapine disease Interactions

There are 14 disease interactions with clozapine which include:

Agranulocytosis Anticholinergic Effects Hepatitis Acute Alcohol Intoxication Cardiovascular Disease Cns Depression Nms

Tardive Dyskinesia Hyperglycemia Renal Dysfunction Dehydration Liver Disease Parkinsonism Seizure Disorders

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