Clozaril (clozapine) and Alcohol / Food Interactions
There are 5 alcohol/food/lifestyle interactions with Clozaril (clozapine) which include:
cloZAPine ↔ Caffeine
Minor Drug Interaction
Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
For clinical details see professional interaction data.
cloZAPine ↔ Alcohol (Ethanol)
Moderate Drug Interaction
Using cloZAPine together with ethanol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with cloZAPine. Do not use more than the recommended dose of cloZAPine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
cloZAPine ↔ food
Moderate Food Interaction
Alcohol can increase the nervous system side effects of cloZAPine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cloZAPine. Do not use more than the recommended dose of cloZAPine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
atypical antipsychotic agents - lipid alterations
Atypical antipsychotic drugs have been associated with undesirable alteration in lipid levels. While all agents in the class have been shown to produce some changes, each drug has its own specific risk profile. Before or soon after initiation of antipsychotic medication, obtain a fasting lipid profile at baseline and monitor periodically during treatment.
Moderate Potential Hazard, Moderate plausibility
atypical antipsychotic agents - weight gain
Weight gain has been observed with atypical antipsychotic use. When treating pediatric patients with these agents, weight gain should be monitored and assessed against that expected for normal growth. Monitor weight at baseline and frequently thereafter. While all agents in the class have been shown to produce some changes, each drug has its own specific risk profile.
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Clozaril (clozapine) drug Interactions
There are 1253 drug interactions with Clozaril (clozapine)
Clozaril (clozapine) disease Interactions
There are 26 disease interactions with Clozaril (clozapine) which include:
- Anticholinergic Effects
- Acute Alcohol Intoxication
- Cardiovascular Disease
- Cns Depression
- Tardive Dyskinesia
- Neuroleptic Malignant Syndrome
- Hematologic Abnormalities
- Lipid Alterations
- Weight Gain
- Renal Dysfunction
- Thromboembolic Events
- Liver Disease
- Seizure Disorders
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
Do not stop taking any medications without consulting your healthcare provider.
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