Anafranil (clomipramine) and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with Anafranil (clomipramine) which include:
Anafranil and Alcohol (Ethanol)
Moderate Drug Interaction
MANAGEMENT: Patients should be warned of this interaction and advised to limit their ethanol intake while taking tricyclic antidepressants. Monitoring for TCA toxicity (CNS depression, excessive anticholinergic effects, hypotension, arrhythmias) is recommended during alcohol withdrawal.
Moderate Food Interaction
MONITOR: Limited data suggest that the administration of clomipramine with grapefruit juice may significantly increase plasma drug concentrations. Clomipramine is initially demethylated by CYP450 1A2, 3A3 and 3A4 before undergoing further metabolism to 8-hydroxyclomipramine. The increase in clomipramine bioavailability may stem from inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. This interaction has occasionally been exploited in attempts to improve symptomatic control of obsessive compulsive disorder.
MANAGEMENT: Patients receiving clomipramine therapy who ingest grapefruits and grapefruit juice should be monitored for adverse effects and undue fluctuations in plasma drug levels.
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Anafranil (clomipramine) drug Interactions
There are 1058 drug interactions with Anafranil (clomipramine)
Anafranil (clomipramine) disease Interactions
There are 10 disease interactions with Anafranil (clomipramine) which include:
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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