Anafranil (clomipramine) Alcohol, Food & Lifestyle Interactions

There are 2 food and lifestyle interactions with Anafranil (clomipramine) which include:

GENERALLY AVOID: The combination of ethanol and a tricyclic antidepressant may result in additive impairment of motor skills, especially driving skills. Also, one study has suggested that clomipramine metabolism is significantly impaired for several weeks or more following discontinuation of chronic alcohol consumption.

MANAGEMENT: Patients should be warned of this interaction and advised to limit their ethanol intake while taking tricyclic antidepressants. Monitoring for TCA toxicity (CNS depression, excessive anticholinergic effects, hypotension, arrhythmias) is recommended during alcohol withdrawal.

MONITOR: Limited data suggest that the administration of clomipramine with grapefruit juice may significantly increase plasma drug concentrations. Clomipramine is initially demethylated by CYP450 1A2, 3A3 and 3A4 before undergoing further metabolism to 8-hydroxyclomipramine. The increase in clomipramine bioavailability may stem from inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. This interaction has occasionally been exploited in attempts to improve symptomatic control of obsessive compulsive disorder.

MANAGEMENT: Patients receiving clomipramine therapy who ingest grapefruits and grapefruit juice should be monitored for adverse effects and undue fluctuations in plasma drug levels.

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Anafranil (clomipramine) drug Interactions

There are 982 drug interactions with Anafranil (clomipramine)

Anafranil (clomipramine) disease Interactions

There are 10 disease interactions with Anafranil (clomipramine) which include:

Seizure Disorders Anticholinergic Effects Cardiovascular Disease Pheochromocytoma Liver Disease

Bone Marrow Suppression Diabetes Renal/Liver Disease Schizophrenia/Bipolar Disorder Tardive Dyskinesia

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