Librax (chlordiazepoxide/clidinium) and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with Librax (chlordiazepoxide/clidinium) which include:

GENERALLY AVOID: Acute ethanol ingestion may potentiate the CNS effects of many benzodiazepines. Tolerance may develop with chronic ethanol use. The mechanism may be decreased clearance of the benzodiazepines because of CYP450 hepatic enzyme inhibition. Also, it has been suggested that the cognitive deficits induced by benzodiazepines may be increased in patients who chronically consume large amounts of alcohol.

MANAGEMENT: Patients should be advised to avoid alcohol during benzodiazepine therapy.

GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.

MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.

benzodiazepines - obesity

The plasma half-lives of benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat. Marked increases in distribution (> 100%) have been reported for diazepam and midazolam, and moderate increases (25% to 100%) for alprazolam, lorazepam, and oxazepam. Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid toxicity.

You should also know about...

Librax (chlordiazepoxide/clidinium) drug Interactions

There are 908 drug interactions with Librax (chlordiazepoxide/clidinium)

Librax (chlordiazepoxide/clidinium) disease Interactions

There are 11 disease interactions with Librax (chlordiazepoxide/clidinium) which include:

Acute Alcohol Intoxication Closed-Angle Glaucoma Drug Dependence Renal/Liver Disease Respiratory Depression Seizures

Prolonged Hypotension Depression Obesity Paradoxical Reactions Porphyria

See also...

• Librax (chlordiazepoxide/clidinium) Side Effects
• Librax (chlordiazepoxide/clidinium) Consumer Information

• Drug Interactions Checker

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