Cefdinir and Alcohol / Food Interactions

There is 1 alcohol/food/lifestyle interaction with cefdinir:

ADJUST DOSING INTERVAL: The oral bioavailability of cefdinir may be significantly decreased by concomitant administration of iron preparations. The proposed mechanism is chelation of cefdinir by the iron cation, forming a complex that is poorly absorbed from the gastrointestinal tract. According to product labeling, concomitant administration of cefdinir with a therapeutic iron supplement containing 60 mg of elemental iron (as ferrous sulfate) or vitamins supplemented with 10 mg of elemental iron resulted in a reduction of cefdinir absorption by 80% and 31%, respectively. In a study of six healthy volunteers, simultaneous administration of cefdinir (200 mg single oral dose) with a sustained-release formulation of ferrous sulfate (1050 mg, equivalent to 210 mg elemental iron) resulted in greater than 90% decreases in the mean peak plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC) of cefdinir compared to administration of cefdinir alone. Even when the iron preparation was administered 3 hours after cefdinir, cefdinir Cmax was still reduced by 25% and AUC by 36%.

MANAGEMENT: To minimize potential interaction with iron, the product labeling recommends that cefdinir be taken at least 2 hours before or 2 hours after administration of iron-containing products. However, this separation time may not be sufficient to prevent the interaction when sustained-release iron products are used, especially in higher dosages. Patients should be advised that reddish stools may occur due to formation of a nonabsorbable complex between cefdinir or its breakdown products and iron in the gastrointestinal tract.

You should also know about...

cefdinir drug Interactions

There are 74 drug interactions with cefdinir

cefdinir disease Interactions

There are 5 disease interactions with cefdinir which include:

Colitis Renal Dysfunction Diabetes

Nitroprusside Tests Dialysis

See also...

• Cefdinir Side Effects
• Cefdinir Consumer Information

• Drug Interactions Checker

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