Acetaminophen/pentazocine and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with acetaminophen/pentazocine which include:

GENERALLY AVOID: Chronic, excessive consumption of alcohol may increase the risk of acetaminophen-induced hepatotoxicity, which has included rare cases of fatal hepatitis and frank hepatic failure requiring liver transplantation. The proposed mechanism is induction of hepatic microsomal enzymes during chronic alcohol use, which may result in accelerated metabolism of acetaminophen and increased production of potentially hepatotoxic metabolites.

MANAGEMENT: In general, chronic alcoholics should avoid regular or excessive use of acetaminophen. Alternative analgesic/antipyretic therapy may be appropriate in patients who consume three or more alcoholic drinks per day. However, if acetaminophen is used, these patients should be cautioned not to exceed the recommended dosage (maximum 4 g/day in adults and children 12 years of age or older).

GENERALLY AVOID: The central nervous system-depressant effects of opioid analgesics and ethanol may be additive. The combination of these agents may result in additive CNS-depression and impairment of judgment, thinking, and psychomotor skills. In more severe cases, respiratory depression, hypotension, profound sedation, and coma can occur. Death has been reported in overdosage.

MANAGEMENT: The concomitant use of opioid analgesics and ethanol should be avoided.

MONITOR: Smoking tobacco may decrease the plasma concentrations and effects of pentazocine by enhancing its metabolic clearance.

MANAGEMENT: The possibility of reduced therapeutic effects of pentazocine should be considered in smokers.

You should also know about...

acetaminophen/pentazocine drug Interactions

There are 750 drug interactions with acetaminophen/pentazocine

acetaminophen/pentazocine disease Interactions

There are 17 disease interactions with acetaminophen/pentazocine which include:

Alcoholism Liver Disease Impaired Gi Motility Infectious Diarrhea Liver Disease Prematurity Renal Dysfunction Acute Mi Drug Dependence

Intracranial Pressure Respiratory Depression Pku Adrenal Insufficiency Biliary Spasm Hypothyroidism Seizure Disorders Urinary Retention

See also...

• Acetaminophen/pentazocine Side Effects
• Acetaminophen/pentazocine Consumer Information

• Drug Interactions Checker

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