Pharmaceutical News and Articles
Print Email

Avandia (rosiglitazone maleate)

February 20, 2007

Audience: Endocrinologists, other healthcare professionals, consumers

Indication: Treatment of type 2 diabetes mellitus
[Posted 02/20/2007] Glaxo SmithKline (GSK) notified healthcare professionals of the results of a randomized, double-blind parallel group study [ADOPT] of 4,360 patients with recently diagnosed type 2 diabetes mellitus followed for 4-6 years to compare glycemic control with rosiglitazone relative to metformin and glyburide monotherapies. Significantly more female patients who received rosiglitazone experienced fractures of the upper arm, hand, or foot, than did female patients who received either metformin or glyburide. At GSK's request, an independent safety committee reviewed an interim analysis of fractures in another large; ongoing; controlled clinical trial and preliminary analysis was reported as being consistent with the observations from ADOPT. Healthcare professionals should consider the risk of fracture when initiating or treating female patients with type 2 diabetes mellitus with rosiglitazone.

[February 2007 - Letter - GSK]

Latest FDA MedWatch Alerts...

FDA MedWatch Alerts Archive

2009: Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov
2008: Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec
2007: Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec
2006: Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec
2005: Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec
2004: Jan | Feb | Mar | Apr | May | Jun | Aug | Sep | Oct | Nov | Dec
2003: Jan | Feb | Apr | May | Jul | Aug | Sep | Oct | Nov | Dec
2002: Feb | Mar | Apr | May | Jun | Jul | Sep | Oct | Nov

More News Resources

Daily MedNews
Pharma Industry News
New Drug Applications
New Drug Approvals
Clinical Trial Results
Generic Drug Approvals
Monthly Update Archive

Services
Home
A to Z Drug List
Drugs by Condition
Drug Side Effects
Natural Products
Community Forums
Interactive Tools
Pill Identifier
Interactions Checker
MedNotes beta
Support Groups beta
Drug Image Search
Phonetic Search
News & Articles
Latest Drug News
FDA Drug Alerts
New Drug Approvals
New Drug Applications
Clinical Trial Results
Medical Encyclopedia
News FeedsRSS Feeds
Health Professionals
Professional Resources
Drugs by Classification
Patient Care Notes
Drug Imprint Codes
Medical Dictionary
Animal Medicine
Veterinary Drugs
Advertise Here
Recent Searches
Thalomid
Lortab
Drixoral
Folic Acid
Synagis
Cyclobenzaprine
Nortriptyline
Clindesse
Tobradex
MS Contin
Sustiva
Onglyza
Propecia
Xenical
Nucynta
Privigen
Ambroxol
Zestril
Zebeta
Megace ES
Actonel
Ammonul
Simponi
Januvia
Synera
Recently Approved
Qutenza
Lysteda
Istodax
Pennsaid
Arzerra
Votrient
Twynsta
Cervarix
Berinert
Stelara
More...

Subscribe to our popular newsletter containing a regular roundup of medication news, alerts and new drug approvals.


MedNotes
Most Popular Internet Searches
Lipitor
Viagra
Zoloft
Crestor
 Cialis
Wellbutrin
Effexor
Celebrex
 Levitra
Neurontin
Paxil
Zocor
Advertisement
Latest Drug Information Updates

Qutenza
Qutenza is a capsaicin transdermal patch for the management of pain due to postherpetic neuralgia.

Lysteda
Lysteda (tranexamic acid) is an antifibrinolytic agent for the treatment of women with menorrhagia, heavy menstrual bleeding (HMB), and its accompanying symptoms.

Pennsaid
Pennsaid is a topical non-steroidal anti-inflammatory drug (NSAID) used for the treatment of signs and symptoms of osteoarthritis of the knee.

Istodax
Istodax (romidepsin) a histone deacetylase (HDAC) inhibitor indicated the treatment of cutaneous T-cell lymphoma.

Cervarix
Cervarix (human papillomavirus bivalent (types 16 and 18) is a is a preventative cervical cancer vaccine for the prevention of cervical pre-cancers and cervical cancer associated with oncogenic human papillomavirus (HPV) types 16 and 18 in girls and young women (aged 10-25).

Votrient
Votrient (pazopanib) is a kinase inhibitor indicated for the treatment of patients with advanced renal cell carcinoma.

Arzerra
Arzerra (ofatumumab) is a CD20-directed cytolytic monoclonal antibody indicated for the treatment of patients with chronic lymphocytic leukemia.

Twynsta
Twynsta (telmisartan/amlodipine) is an angiotensin II receptor blocker (ARB) and a dihydropyridine calcium channel blocker (DHP-CCB) combination product indicated for the treatment of hypertension alone or with other antihypertensive agents.

Berinert
Berinert (C1-esterase inhibitor (human)) is a plasma derived C1 Esterase Inhibitor indicated for the treatment of acute abdominal or facial attacks of hereditary angioedema (HAE) in adult and adolescent patients.

Stelara
Stelara (ustekinumab) is a human monoclonal antibody for the treatment of moderate to severe plaque psoriasis.

Influenza A (H1N1) 2009 Monovalent Vaccine
Influenza A (H1N1) 2009 Monovalent Vaccine is an inactivated influenza virus vaccine indicated for active immunization of persons ages 18 years of age and older against influenza disease caused by pandemic (H1N1) 2009 virus.

Zirgan
Zirgan (ganciclovir ophthalmic gel) is a topical ophthalmic antiviral preparation for the treatment of acute herpetic keratitis (dendritic ulcers).

Vibativ
Vibativ (telavancin) is a bactericidal, once-daily injectable antibiotic for the treatment of complicated skin and skin structure infections (cSSSI) caused by susceptible Gram-positive bacteria, including Staphylococcus aureus, both methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) strains.

Folotyn
Folotyn (pralatrexate) is a folate analogue metabolic inhibitor indicated for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL).

Valturna
Valturna is a combination of aliskiren (a direct renin inhibitor) and valsartan (an angiotensin II receptor blocker) indicated for the treatment of high blood pressure.

More...

(web1)