Waterhouse-Friderichsen syndrome is failure of the adrenal gland to function as as result of bleeding into the gland.
Causes of Waterhouse-Friderichsen syndrome
This condition is caused by severe infection with meningococcus bacteria or other severe infection from bacteria, such as:
- Group B streptococcus
- Pseudomonas aeruginosa
- S. pneumoniae
- Staphylococcus aureus
Rarely, Waterhouse-Friderichsen syndrome can be caused by the use of medications that promote blood clotting. Other causes include:
- Low platelet counts
- Primary antiphospholipid syndrome
- Renal vein thrombosis
- Steroid use
It is deadly if the underlying cause of this syndrome is not treated right away.
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Maitra A. The endocrine system. In: Kumar V, Abbas AK, Fausto N, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia, PA: Saunders Elsevier; 2009:chap 24.
White PC. Adrenocortical insufficiency. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 569.
|Review Date: 9/1/2013
Reviewed By: Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.