Pyruvate kinase
Pyruvate kinase is an enzyme found in red blood cells that helps change sugar in the blood (glucose) to energy when oxygen levels are low.
This article discusses the test to measure the level of pyruvate kinase in your blood.
Why is the Test Performed?
This test is done to detect abnormally low levels of pyruvate kinase. If you do not have enough of this enzyme, red blood cells break down faster than normal. This can lead to hemolytic anemia, which is a low red blood cell count caused by an accelerated destruction of red blood cells.
See also: Pyruvate kinase deficiency (PKD)
How is the Test Performed?
A blood sample is needed. For information on how this is done, see: Venipuncture
In the laboratory, white blood cells are removed because they can alter test results. The level of pyruvate kinase is then measured.
Preparation for the Test
If your child is to have this test performed, it may be helpful to explain how the test will feel, and even demonstrate on a doll. Explain the reason for the test. Knowing the "how and why" may reduce the anxiety your child feels.
How will the Test Feel?
When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterwards, there may be some throbbing.
Pyruvate kinase Risks
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling light-headed
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Normal Results for Pyruvate kinase
Results vary depending upon the testing method used. In general, a normal value is 179 ± 16 units per 100mL of red blood cells.
Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.
What Abnormal Results Mean
Low levels confirm pyruvate kinase deficiency.
Learn more about Pyruvate kinase
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network; Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
Copyright 2012 A.D.A.M., Inc.
