Home Medical Encyclopedia Disease P Polyarteritis nodosa

Polyarteritis nodosa

Alternative Names: Periarteritis nodosa

Polyarteritis nodosa is a serious blood vessel disease in which small and medium-sized arteries become swollen and damaged.

Causes of Polyarteritis nodosa

Polyarteritis nodosa is a disease of unknown cause that affects arteries, the blood vessels that carry oxygenated blood to organs and tissues. It occurs when certain immune cells attack the affected arteries.

More adults than children get this disease. It damages the tissues supplied by the affected arteries because the tissues aren't receiving the oxygen and nourishment they need.

People with active hepatitis B and C may develop this disease.

Polyarteritis nodosa Symptoms

Symptoms result from damage to affected organs, often the skin, heart, kidneys, and nervous system.

Generalized symptoms include:

Nerve involvement may cause sensory changes with numbness, pain, burning, and weakness. Central nervous system involvement may cause strokes or seizures. Kidney involvement can produce varying degrees of renal (kidney) failure.

When heart arteries are involved, heart attack, heart failure, and inflammation of the sac around the heart (pericarditis) can occur.

Tests and Exams

There are no specific lab tests for diagnosing polyarteritis nodosa. Diagnosis is based on the physical examination and a few laboratory studies that help to confirm the diagnosis:

  • Arteriogram to see any changes in the smaller arteries
  • CBC may show a higher than normal white blood count
  • ESR or CRP is often higher than normal
  • Tissue biopsy reveals inflammation in small arteries, called arteritis
  • Immunoglobulins may be increased

Treatment of Polyarteritis nodosa

Treatment involves medications to suppress the immune system, including prednisone and cyclophosphamide.

For polyarteritis nodosa related to hepatitis, treatment may involve plasmapheresis and anti-viral medicines.

Prognosis (Outlook)

Current treatments using steroids and other drugs that suppress the immune system (such as cyclophosphamide) can improve symptoms and the chance of long-term survival. The most serious associated conditions generally involve the kidneys and gastrointestinal tract. Without treatment, the outlook is poor.

Potential Complications

When to Contact a Health Professional

Call your health care provider if you develop symptoms of this disorder. Early diagnosis and treatment may improve the chance of a good outcome.

Prevention of Polyarteritis nodosa

There is no known prevention. However, early treatment can prevent some damage and symptoms.

Sergent JS. Polyarteritis and related disorders. In: Harris ED Jr., Budd RC, Genovese MC, Firestein GS, Sargent JS, eds. Kelley's Textbook of Rheumatology. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2008: chap 83.

Stone JH. The systemic vasculitides. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 291.

Related Images

Learn more about Polyarteritis nodosa

Review Date: 9/7/2010
Reviewed By: Mark James Borigini, MD, Associate Clinical Professor of Medicine, University of California, Irvine, Irvine, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
Do not use this information for medical emergencies - Call 911. This information should not be used for the diagnosis or treatment of any medical condition. A licensed medical practitioner should always be consulted for diagnosis and treatment of any and all medical conditions. Links to other websites do not constitute endorsements and are provided for information only. Any duplication or distribution of this information is strictly prohibited.
Copyright 2011 A.D.A.M., Inc.
(web6)