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Macroamylasemia

Definition

Macroamylasemia is the presence of an abnormal substance called macroamylase in the blood.

Causes

Macroamylase is a molecule that consists of an enzyme, called amylase, which is attached to a protein. Because it is relatively large, macroamylase is filtered very slowly from the blood by the kidneys.

Macroamylasemia has been associated with:

• Celiac disease
• Lymphoma
• HIV infection
• Monoclonal gammopathy
• Rheumatoid arthritis
• Ulcerative colitis

Symptoms

Macroamylasemia does not cause symptoms.

Exams and Tests

A blood test will show high levels of amylase. However, macroamylasemia can be confused with acute pancreatitis, which also causes high levels of amylase in the blood.

Macroamylasemia can be diagnosed by measuring amylase levels in the urine. Urine levels of amylase would be low. (Urine amylase levels are high in patients with acute pancreatitis.)

Owyang C. Pancreatitis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 147.

Review Date: 10/18/2008
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.