The symptoms involved in CREST syndrome are associated with the generalized form of the disease Systemic sclerosis (scleroderma). CREST is an acronym for the clinical features that are seen in a patient with this disease. The â€œCâ€ stands for calcinosis, where calcium deposits form under the skin on the fingers or other areas of the body. The â€œRâ€, stands for Raynaud's phenomenon, spasm of blood vessels in the fingers or toes in response to cold or stress. The â€œEâ€ represents esophageal dysmotility, which can cause difficulty in swallowing. The â€œSâ€ is for sclerodactyly, tightening of the skin causing the fingers to bend. Finally, the letter â€œTâ€ is for telangiectasia, dilated vessels on the skin of the fingers, face, or inside of the mouth.Â
Usually only 2 of the five symptoms of the CREST syndrome is necessary to be diagnosed with the disease.
|Review Date: 2/21/2013
Reviewed By: Ariel D. Teitel, MD, MBA, Clinical Associate Professor of Medicine, NYU Langone Medical Center. Review provided by VeriMed Healthcare Network. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.