Hypersplenism

Hypersplenism is an overactive spleen. The spleen is an organ found in the upper left side of your belly area. The spleen helps filter old and damaged cells from your bloodstream. If your spleen is overactive, it removes the blood cells too early and too quickly.

The spleen plays an important role in helping your body fight infections. Problems with the spleen can make you more likely to develop infections.

Causes of Hypersplenism

Hypersplenism can be caused by:

• Cirrhosis
• Lymphoma
• Malaria
• Tuberculosis
• Various connective tissue and inflammatory diseases

Hypersplenism Symptoms

Symptoms include:

• Enlarged spleen
• Low level of one or more types of blood cells
• Premature feeling of fullness after eating
• Stomach pain on the left side

Ferri FF. Ferri's Clinical Advisor 2007: Instant Diagnosis and Treatment. 9th ed. Philadelphia, Pa: Mosby; 2007:443.

Hoffman R, Benz Jr. EJ, Shattil SJ, et al., eds. Hematology: Basic Principles and Practice. 4th ed. Philladelphia, Pa: Churchill Livingston; 2005:711-12.

Spleen

Review Date: 1/24/2011
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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