Human placental lactogen
Alternative Names: HPL; Human chorionic somatomammotropin; HCS
Human placental lactogen (hPL) is a hormone produced by the placenta, the organ that develops during pregnancy to help feed the growing baby. This hormone breaks down fats from the mother to provide fuel for the the growing baby. It can lead to insulin resistance and carbohydrate intolerance in the mother.
A test can be done to measure the amount of hPL in the blood. The test is only done on pregnant women.
Why is the Test Performed?
The test is done to see how well the placenta is functioning.
How is the Test Performed?
Blood is drawn from a vein, usually on the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic, and an elastic band is placed around the upper arm to apply pressure and restrict blood flow through the vein. This causes veins below the band to fill with blood.
A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. During the procedure, the band is removed to restore circulation. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
Preparation for the Test
No special preparation is needed.
How will the Test Feel?
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Human placental lactogen Risks
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others. Other risks are rare, but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Considerations
The uses of this test are limited to certain rare conditions and medical research.
Normal Results for Human placental lactogen
A rising HPL value during pregnancy is normal.
What Abnormal Results Mean
Abnormal results may be a sign of abnormal (usually insufficient) placenta function.
HPL values are decreased with:
HPL values are increased with:
- Multiple pregnancies (twins or more)
- Placental site trophoblastic tumor
- Intact molar pregnancy
- Diabetes
- Rh incompatibility
Learn more about Human placental lactogen
Reviewed By: Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; and Susan Storck, MD, FACOG, Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, Washington; Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
Copyright 2011 A.D.A.M., Inc.
