Herpes esophagitis

Herpes esophagitis is a viral infection that involves inflammation and ulcers in the esophagus, the tube that carries food from the mouth to the stomach.

Causes of Herpes esophagitis

The herpes simplex virus causes herpes esophagitis.

Infection of the esophagus by the herpes simplex virus is rare in people with normal immune systems and usually runs its course without treatment. However, severe and difficult-to-treat esophagitis can occur in people with a suppressed or weakened immune system.

The following raise your risk for herpes esophagitis:

• HIV/AIDS
• Chemotherapy
• Diabetes
• Leukemia or lymphoma
• Organ transplants
• Other conditions that suppress or weaken your immune system

Herpes esophagitis Symptoms

Symptoms include:

• Chills
• Difficulty swallowing
• Fever
• Herpes in the mouth (herpes labialis)
• Joint pain or other general symptoms
• Painful swallowing

Tests and Exams

• Culture of cells from the esophagus
• Esophagogastroduodenoscopy (EGD) with or without biopsy

Treatment of Herpes esophagitis

In most people, antiviral medication such as acyclovir, famciclovir, or valacyclovir can control the infection. Some people also need pain medicine. Many people who are treated for an episode of herpes esophagitis need other, long-term medicines to suppress the virus and prevent reinfection.

Prognosis (Outlook)

Esophagitis can usually be treated effectively. Healthy people recover on their own in 3 - 5 days, but those with a weakened immune system take longer to get better.

The outcome depends upon the immune system problem that makes the person more likely to develop the infection.

Potential Complications

• Holes in your esophagus (perforations)
• Infection at other sites
• Recurrent infection

When to Contact a Health Professional

Call your health care provider if you have any condition that can cause reduced immune response and you develop symptoms of herpes esophagitis.

Prevention of Herpes esophagitis

The herpes simplex virus is contagious by direct contact, so avoid contact with known herpes sores (lesions).

Whitley RJ. Herpes simplex infections. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 397.

Herpetic esophagitis	Upper gastrointestinal system

Review Date: 8/28/2009
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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