Hemorrhagic disease of the newborn
Definition
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Hemorrhagic disease of the newborn is a bleeding disorder that usually develops shortly after a baby is born.
See also: Hemolytic disease of the newborn
Alternative Names
Vitamin k deficiency bleeding; VKDB
Causes
A lack of vitamin K causes hemorrhagic disease of the newborn. Vitamin K is a fat-soluble vitamin that plays an important role in blood clotting.
Babies usually have low levels of vitamin K for a variety of reasons. Vitamin K doesn't move easily across the placenta so a newborn doesn't have much vitamin K stored up at birth. Also, there isn't much vitamin K in breast milk.
Your baby may develop this condition if:
- A preventive vitamin K shot is not given at birth
- You exclusively breastfeed your baby
- You take certain anti-seizure drugs
The condition is grouped into three categories:
- Early onset
- Classic onset (this is typically the type associated with the name, hemorrhagic disease of the newborn)
- Late onset
Early onset hemorrhagic disease of the newborn is very rare. It occurs during the first hours of birth and certainly within 24 hours. The main risk factor is the use of anti-seizure drugs or a blood thinner called coumadin during pregnancy.
Classic onset disease is also rare. It develops in breastfed infants within the first week after birth.
The late onset form is seen in infants older than 2 weeks up to 2 months old. It is particularly common in children of Asian descent.
Risk factors include:
- Alpha1-antitrypsin deficiency
- Biliary atresia
- Breastfeeding
- Celiac disease
- Cystic fibrosis
- Diarrhea
- Hepatitis
Symptoms
The condition causes bleeding. The most common areas of bleeding include:
- A boy's penis if he has been circumcised
- Belly button area
- Gastrointestinal tract (may result in blood in the baby's bowel movements)
- Mucus membranes (such as the lining of the nose and mouth)
- Places where there has been a needle stick
There may also be:
- Blood in the urine
- Bruising
- Raised lump on the baby's head (suggesting bleeding underneath one of the skull bones)
Exams and Tests
Blood clotting tests will be done.
The diagnosis is confirmed if a vitamin K shot stops the bleeding and blood clotting time (prothrombin time) is within normal limits.
Treatment
Vitamin K is given if bleeding occurs. Patients with severe bleeding may need blood transfusions.
Outlook (Prognosis)
The outlook tends to be worse for babies with late-onset hemorragic disease than other forms. There is a higher rate of bleeding inside the skull (intracranial hemorrhage) associated with the late onset condition.
Possible Complications
- Bleeding inside the skull (intracranial hemorrhage), with possible brain damage
- Death
- Severe bleeding
When to Contact a Medical Professional
Call your doctor if your baby has any unexplained bleeding.
Prevention
The American Academy of Pediatrics recommends giving every baby a shot of vitamin K immediately after birth. This practice has helped prevent the condition, which is now rare in the U.S.
The early onset form of the disease may be prevented by giving vitamin K shots to pregnant women who take anti-seizure medications.
Blood Disorders. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 103.
Reviewed By: Mark A Fogel, MD, FACC, FAAP, Associate Professor of Pediatrics and Radiology, Director of Cardiac MR, The Children's Hospital of Philadelphia, Division of Cardiology, Philadelphia, PA. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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