Fractional excretion of sodium

Fractional excretion of sodium (FENa) is the amount of salt (sodium) that leaves the body through urine compared to the amount filtered and reabsorbed by the kidney.

FENa is not a test. Instead it is a calculation based on the concentrations of sodium and creatinine in the blood and urine. Urine and blood chemistry tests are needed to perform this calculation.

Blood and urine samples are collected at the same time and sent to a lab. There, they are examined for salt (sodium) and creatinine levels.

Eat your normal foods with a normal amount of salt, unless otherwise instructed by your doctor.

If needed, you may be told to temporarily stop medicines that interfere with test results. For example, some diuretic medicines (water pills) can affect test results.

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. This soon goes away.

The test is usually done for persons who are very ill with acute kidney disease. The test helps determine if the drop in urine production is due to reduced blood flow to the kidney or to kidney damage itself.

A meaningful interpretation of the test can be made only when your urine volume has dropped to less than 500 milliliters per day (mL/day).

FENa of lower than 1% indicates decreased blood flow to the kidney. This can occur with kidney damage due to dehydration or heart failure.

FENa higher than 1% suggests damage to the kidney itself.

Fractional excretion of sodium Risks

Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

  • Excessive bleeding
  • Fainting or feeling lightheaded
  • Hematoma (blood accumulating under the skin)
  • Infection (a slight risk any time the skin is broken)
  • Multiple punctures to locate veins

There are no risks with the urine sample.

References

Emmet M, Fenves AZ, Schwartz JC. Approach to the patient with kidney disease. In: Taal MW, Chertow GM, Marsden PA, et al., eds. Brenner and Rector's The Kidney. 9th ed. Philadelphia, Pa: Elsevier Saunders; 2011:chap 24.

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Review Date: 11/7/2013
Reviewed By: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.
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