CSF-VDRL test

Alternative Names: Venereal disease research laboratory slide test - CSF

The CSF-VDRL test is used to diagnose neurosyphilis. It looks for substances called reagins, which are sometimes produced by the body in reaction to the syphilis-causing bacteria.

See also: VDRL

Why is the Test Performed?

The CSF-VDRL test is done to diagnose syphilis in the brain or spinal cord. Brain and spinal cord involvement is usually a sign of late stage syphilis.

Blood screening tests (VDRL and RPR) are better at detecting middle stage (secondary) syphilis.

How is the Test Performed?

A sample of spinal fluid is needed. For information on how this is taken, see: Lumbar puncture (spinal tap)

Normal Results for CSF-VDRL test

A negative result is normal.

However, false-negatives can occur. This means you can have syphilis even if this test is normal. Therefore, a negative test does not always rule out the disease. Other signs and tests may be used to diagnose neurosyphilis.

What Abnormal Results Mean

A positive result is abnormal and is a sign of neurosyphilis.

CSF test for syphilis

Review Date: 8/24/2011
Reviewed By: Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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