Bladder biopsy

Bladder biopsy is a procedure that involves removing a small piece of tissue from the bladder to be examined under a microscope.

How is the Test Performed?

A bladder biopsy can be done as a part of a cystoscopy (examination of the inside of the bladder). A small piece of tissue or the entire area of concern is removed and sent to the lab to be tested if:

  • Abnormalities of the bladder are found during this examination
  • A tumor is seen

Preparation for the Test

You must sign an informed consent form before you have a bladder biopsy. Usually you are asked to urinate just before the procedure. You may also be asked to take an antibiotic before the procedure.

For infants and children, the preparation you can provide for this test depends on your child's age, previous experiences, and level of trust. For general information regarding how you can prepare your child, see the following topics:

How will the Test Feel?

There may be slight discomfort as the cystoscope (a lighted instrument used to look at the bladder) is passed through your urethra into your bladder. You will feel an uncomfortable sensation -- similar to a strong urge to urinate -- when the fluid has filled your bladder.

You may feel a pinch during the biopsy. There may be a burning sensation when the blood vessels are sealed to stop bleeding (cauterized).

After the cystoscope is removed, your urethra may be sore. You may experience a burning sensation during urination for a day or two.

Sometimes when the suspicious area is larger, you will need general or spinal anesthesia to remove the area in question.

Why is the Test Performed?

This test is most often performed to check for cancer of the bladder or urethra.

Normal Results for Bladder biopsy

The bladder wall is smooth. The bladder is of a normal size, shape, and position. There are no obstructions, growths, or stones.

What Abnormal Results Mean

The presence of cancer cells indicates bladder cancer. The type of cancer can be determined from the biopsy sample.

Other abnormalities may include:

Bladder biopsy Risks

There is some risk of urinary tract infection.

There is a slight risk of excessive bleeding or rupturing of the bladder wall with the cystoscope or during biopsy.

Considerations

You will usually have a small amount of blood in your urine shortly after this procedure. If the bleeding continues after you urinate, contact your health care provider.

Also contact your health care provider if:

  • You have pain, chills, or a fever
  • You are producing less urine than usual (oliguria)
  • You cannot urinate despite a strong urge to do so

References

Duffey B, Monga M. Principles of endoscopy. In: Wein AJ, ed. Campbell-Walsh Urology. 10th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 8.

Coburn M. Urologic surgery. In: Townsend CM Jr., Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 19th ed. Philadelphia, Pa: Saunders Elsevier; 2012:chap 73.

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Review Date: 6/18/2012
Reviewed By: Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington; and Scott Miller, MD, Urologist in private practice in Atlanta, Georgia. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2014 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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