B-cell leukemia/lymphoma panel

Alternative Names: B lymphocyte cell surface markers

B-cell leukemia/lymphoma panel is a test that looks for certain proteins on the surface of white blood cells called B-lymphocytes. The proteins serve as markers that may be helpful in diagnosing leukemia or lymphoma.

Why is the Test Performed?

This test may be performed:

• When other tests (such as a blood smear) indicate abnormal white blood cells
• When leukemia or lymphoma is suspected
• To determine the type of leukemia or lymphoma

How is the Test Performed?

A blood sample is needed. For information on how this is done, see: Venipuncture

Less commonly, white blood cells are removed during a bone marrow biopsy. The sample may also be taken during after a lymph node biopsy or other biopsy when lymphoma is suspected.

The blood sample is sent to a laboratory, where the specialist checks the cell type and characteristics. This procedure is called immunophenotyping. The test is usually done using a technique called flow cytometry.

Preparation for the Test

No special preparation is usually necessary.

How will the Test Feel?

When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.

B-cell leukemia/lymphoma panel Risks

Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

• Excessive bleeding
• Fainting or feeling light-headed
• Hematoma (blood accumulating under the skin)
• Infection (a slight risk any time the skin is broken)

Considerations

This test is highly specialized and may not be available at all general laboratories.

What Abnormal Results Mean

• B-cell lymphocytic leukemia
• Lymphoma

Blood test

Review Date: 2/28/2011
Reviewed By: Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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