Antiparietal cells antibodies
Definition
This is a test to measure the presence of antibodies against the parietal cells of the stomach. The parietal cells secrete intrinsic factor and stomach acid.
Alternative Names
APCA; Anti-gastric parietal cell antibodiesWhy the Test is Performed
Your health care provider may use this test to aid in the diagnosis of pernicious anemia. Other tests are also used to help with the diagnosis.
How the Test is Performed
Blood is drawn from a vein and sent to the lab, where the serum (liquid portion of the blood) is separated from the cells. A sample of the serum is placed on a slide with samples from a mouse kidney and stomach, which contain parietal cells. If the patient's serum has parietal cell antibodies, they will react with the parietal cells on the slide.
How to Prepare for the Test
No special preparation is necessary.
Considerations
Less than 2% of the general population test positive for antiparietal cell antibodies, but that percentage increases with age. In people over 60, up to 16% may test positive for antiparietal cell antibodies.
Normal Results
Negative.
What Abnormal Results Mean
A positive test result may indicate:
- Pernicious anemia
- Atrophic gastritis
- Gastric ulcer
- Thyroid disease
- Iron deficiency anemia
- Diabetes
Reviewed By: Jenifer K. Lehrer, MD, Department of Gastroenterology, Frankford-Torresdale Hospital, Jefferson Health System, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
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