zyloprim and Moexipril Interactions

Interactions between zyloprim(allopurinol) and Moexipril (moexipril)

allopurinol and moexipril (Major Drug-Drug)

MONITOR CLOSELY: Allopurinol and angiotensin converting enzyme inhibitors (ACE inhibitors) given concomitantly may increase the risk of hypersensitivity reactions such as Stevens-Johnson syndrome, skin eruptions, anaphylaxis, fever and arthralgias. The mechanism is not known, but impaired renal function may be a predisposing factor. Case reports exist for captopril and enalapril.

MANAGEMENT: Allopurinol should only be used with ACE inhibitors if benefit outweighs risk. If these agents must be administered together, monitor for hypersensitivity reactions and discontinue therapy if needed. Patients should be advised to seek medical help if they develop dyspnea, throat constriction, swelling or hives of the face, lips, or tongue, urticaria, rash, fever, arthralgia, or myalgia.