zidovudine and Rebif Interactions

Interactions between zidovudine and Rebif (interferon beta-1a)

zidovudine and interferon beta-1a (Major Drug-Drug)

MONITOR CLOSELY: The coadministration of interferons and zidovudine (AZT) may result in severe bone marrow toxicity, most often manifested as granulocytopenia and/or thrombocytopenia. These agents are individually myelotoxic, with potentially additive or synergistic effects.

MANAGEMENT: Caution is advised if concomitant therapy is necessary, particularly with the alfa interferons. Complete blood counts, differential and platelet counts should be performed regularly and drug dosages adjusted accordingly. Patients should be advised to promptly report symptoms such as chills, fever, sore throat, pale skin, or unusual fatigue to their physician. Cessation of one or all drugs may be necessary if toxicity develops.