ziagen and Dehydrated alcohol Interactions

Interactions between ziagen(abacavir) and Dehydrated alcohol (ethanol)

ethanol and abacavir (Minor Drug-Drug)

Consumption of ethanol during treatment with abacavir results in a decrease in elimination of abacavir due to the inhibition of alcohol dehydrogenase. Coadministration of alcohol 0.7 g/kg (equivalent to 5 drinks) and abacavir resulted in a 41% increase in the area under the time concentration curve and a 26% increase in elimination half life. The clinical significance of this interaction is unknown.