zaroxolyn and Propulsid Interactions

Interactions between zaroxolyn(metolazone) and Propulsid (cisapride)

metolazone and cisapride (Major Drug-Drug)

CONTRAINDICATED: Some diuretics may produce hypokalemia and hypomagnesemia which could potentiate the risk of cisapride-induced arrhythmias in patients receiving both drugs concomitantly. Prolonged QT interval, torsades de pointes, and death have been reported.

MANAGEMENT: Cisapride is contraindicated in patients with uncorrected hypokalemia and hypomagnesemia, such as those taking potassium-wasting diuretics.