zaroxolyn and 5 fu Interactions

Interactions between zaroxolyn(metolazone) and 5 fu (fluorouracil)

fluorouracil and metolazone (Moderate Drug-Drug)

MONITOR: Antineoplastic-induced bone marrow suppression may be prolonged with concomitant thiazide administration. The mechanism is unknown. Thiazides have been associated with blood dyscrasias.

MANAGEMENT: Alternative antihypertensive therapy may be advisable. Hematological status should be closely monitored in patients receiving this combination.