Interactions between zantac(ranitidine) and Cefditoren (cefditoren)
ranitidine and cefditoren (Moderate Drug-Drug)
GENERALLY AVOID: The coadministration with H2-receptor antagonists or other agents that reduce stomach acid (e.g., proton pump inhibitors) may reduce the oral absorption and plasma concentrations of cefditoren pivoxil. According to the manufacturer, a single intravenous dose of famotidine (20 mg) reduced the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of a single dose of cefditoren pivoxil (400 mg, administered following a meal) by 27% and 22%, respectively. The clinical significance of these alterations is unknown.
MANAGEMENT: The manufacturer recommends that cefditoren pivoxil not be administered concomitantly with H2-receptor antagonists or other agents that reduce stomach acid.
