Interactions between zantac(ranitidine) and Atazanavir (atazanavir)
ranitidine and atazanavir (Moderate Drug-Drug)
ADJUST DOSING INTERVAL: Concurrent administration of H2-receptor antagonists may decrease the oral bioavailability of atazanavir and substantially reduce its concentrations in plasma. Atazanavir solubility decreases with increasing pH, thus inhibition of gastric acid secretion may interfere with dissolution of the drug. Subtherapeutic antiretroviral drug levels may lead to reduced viral susceptibility and development of resistance.
MANAGEMENT: To lessen the effect of H2-receptor antagonists on atazanavir systemic exposure, the medications should be administered as far apart as possible, preferably 12 hours apart.
