zalcitabine and Pentamidine Interactions

Interactions between zalcitabine and Pentamidine (pentamidine)

pentamidine and zalcitabine (Major Drug-Drug)

GENERALLY AVOID: Coadministration of intravenous pentamidine with didanosine or zalcitabine may increase the risk of pancreatitis. These drugs have individually been associated with pancreatitis and additive toxicity may occur during concomitant use. Fatalities have been reported.

MANAGEMENT: The manufacturer recommends that the antiretroviral drugs should be interrupted, if clinically feasible, when treatment with intravenous pentamidine is initiated. If concomitant use cannot be avoided, patients should be closely monitored for clinical and laboratory signs of pancreatitis.