yohimar and Surmontil Interactions

Interactions between yohimar(yohimbine) and Surmontil (trimipramine)

trimipramine and yohimbine (Moderate Drug-Drug)

GENERALLY AVOID: Some antidepressants such as the tricyclics may potentiate the pressor effect of yohimbine. The mechanism is a synergistic sympathomimetic effect due to stimulation of norepinephrine release by yohimbine and inhibition of norepinephrine reuptake by certain antidepressants.

MANAGEMENT: Yohimbine should be avoided in patients undergoing concurrent treatment with tricyclic antidepressants or other drugs that interfere with neuronal uptake or metabolism of norepinephrine.