yocon and Selegiline Interactions

Interactions between yocon(yohimbine) and Selegiline (selegiline)

selegiline and yohimbine (Moderate Drug-Drug)

GENERALLY AVOID: Theoretically, yohimbine may precipitate severe hypertensive reactions and hyperpyrexia in patients treated with monoamine oxidase inhibitors (MAOIs). Yohimbine has been shown to induce the release of norepinephrine in patients with essential hypertension. This action could produce a synergistic sympathomimetic effect with MAOIs, which enhance norepinephrine storage in adrenergic neurons.

MANAGEMENT: While clinical data are lacking, yohimbine should preferably not be used with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, procarbazine). At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with yohimbine.