xopenex-hfa and Acetazolamide Interactions

Interactions between xopenex-hfa(levalbuterol) and Acetazolamide (acetaZOLAMIDE)

acetaZOLAMIDE and levalbuterol (Moderate Drug-Drug)

MONITOR: Beta-2 adrenergic agonist bronchodilators may cause hypokalemia and/or prolongation of the QT interval. The coadministration of potassium-wasting diuretics may exacerbate hypokalemia, potentially increasing the risk of ventricular arrhythmias including ventricular tachycardia and torsade de pointes. Patients who are taking systemic or nebulized beta agonists, high doses of beta agonists, or concomitant theophylline or corticosteroids may be at a greater risk of developing hypokalemia.

MANAGEMENT: Caution is advised when beta-2 agonists must be used concomitantly with diuretics. Close clinical and laboratory monitoring of potassium status is recommended. Patients should be advised to notify their physician if they experience weakness, lethargy, irregular heartbeats, muscle pain or cramps, dizziness, lightheadedness, syncope, irregular heartbeats, or tachycardia.