xenical and Amiodarone Interactions

Interactions between xenical(orlistat) and Amiodarone (amiodarone)

amiodarone and orlistat (Minor Drug-Drug)

Orlistat may reduce the bioavailability of oral amiodarone and its active metabolite, N-desethylamiodarone. After administration of orlistat 120 mg three times daily for 5 to 13 days and single doses of amiodarone 1200 mg to healthy subjects, the area under the concentration-time curve (AUC) and maximum plasma concentration of amiodarone and its metabolite were decreased by 20 to 25%. The proposed mechanism is alteration of the gastrointestinal lipid phase due to inhibition of dietary fat absorption by orlistat, which may decrease the absorption of highly lipophilic drugs. The clinical significance is unknown. Until more information is available, it is recommended that patients be monitored for altered efficacy of amiodarone when orlistat is added to or discontinued from their regimen.