wytensin and Aquacot Interactions

Interactions between wytensin(guanabenz) and Aquacot (trichlormethiazide)

guanabenz and trichlormethiazide (Moderate Drug-Drug)

MONITOR: The hypotensive effects of thiazide diuretics and alpha-adrenergic blockers may be additive. Postural hypotension may occur.

MANAGEMENT: Hemodynamic responses should be monitored during coadministration, especially during the first few weeks of therapy. Patients should be advised to take the alpha-blocker at bedtime and to notify their physician if they experience dizziness or syncope while awake.