welchol and Amiodarone Interactions

Interactions between welchol(colesevelam) and Amiodarone (amiodarone)

amiodarone and colesevelam (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Colesevelam may decrease the gastrointestinal absorption of coadministered drugs. An approximately 20% to 30% reduction in systemic exposure (AUC) has been reported for ethinyl estradiol, glyburide, levothyroxine, and verapamil.

MANAGEMENT: In general, drugs with a narrow therapeutic index as well as those that have been shown to interact with colesevelam should be administered at least 4 hours before the colesevelam dose. Clinical and laboratory monitoring of drug levels and effects should be considered.