vioxx and Aleve caplet Interactions

Interactions between vioxx(rofecoxib) and Aleve caplet (naproxen)

naproxen and rofecoxib (Moderate Drug-Drug)

GENERALLY AVOID: Concomitant use of COX-2 inhibitors with other nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the potential for serious gastrointestinal toxicity including inflammation, bleeding, ulceration, and perforation. The risk is dependent on both dosage and duration of therapy.

MANAGEMENT: The use of COX-2 inhibitors with non-aspirin NSAIDs should be avoided.