vesanoid and Accutane Interactions

Interactions between vesanoid(tretinoin) and Accutane (isotretinoin)

isotretinoin and tretinoin (Moderate Drug-Drug)

GENERALLY AVOID: Concomitant use of a retinoid with vitamin A or other retinoids may result in hypervitaminosis A and additive toxic effects (i.e. hepatotoxicity).

MANAGEMENT: Patients receiving retinoid therapy should avoid concurrent use of other retinoids or vitamin A supplements in excess of minimum recommended daily allowances. Patients should be made aware of vitamin A sources in vitamin supplements, fortified foods, and over-the-counter medications, and be advised to notify their physician if they experience potential signs of hypervitaminosis A such as dry, scaly skin, alopecia, pruritus, erythema, headache, vertigo, and nausea.