vardenafil and E e s 400 filmtab Interactions

Interactions between vardenafil and E e s 400 filmtab (erythromycin)

erythromycin and vardenafil (Major Drug-Drug)

ADJUST DOSE: Coadministration with erythromycin may significantly increase the plasma concentrations of vardenafil. The mechanism is erythromycin inhibition of CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of vardenafil. According to vardenafil labeling, coadministration of erythromycin (500 mg three times a day) and vardenafil (5 mg) resulted in a 3-fold increase in the peak plasma concentration (Cmax) and a 4-fold increase in the area under the concentration-time curve (AUC) of vardenafil.

MANAGEMENT: Patients treated with erythromycin should not receive more than a single 5 mg dose of vardenafil within a 24-hour period. Patients should be advised to promptly notify their physician if they experience pain or tightness in the chest or jaw, irregular heartbeat, nausea, shortness of breath, visual disturbances, syncope, or prolonged erection (greater than 4 hours).